Is Lube Safe: By Type, Sexual Activity, & Ingredients To Avoid The most pregnancy friendly lubricants are the water based kinds. These lubes are water soluble, which means they dissolve in water. They're safer for you and your baby, typically because they contain fewer chemicals than PreSeed is the first sperm friendly vaginal lubricant recommended for women who are trying to conceive but experience vaginal dryness during sexual intercourse. Most other lubricants either kill sperm or alter the morphology motility The lubricant in your drawer could be the one thing you never thought to question. Comment the word CONCEIVE and I will send you a free guide to optimizing your conception window.