Is Your Lube Toxic to Your Fertility: Find a Reproductively Friendly Option Dr Lora Shahine When trying to conceive, choosing the right lubricant matters. Some common products like oil based lubricants, petroleum jelly, saliva, and regular lubricants may harm sperm and reduce fertility chances. Instead, opt for fertility friendly, Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your PreSeed is the first sperm friendly vaginal lubricant recommended for women who are trying to conceive but experience vaginal dryness during sexual intercourse. Most other lubricants either kill sperm or alter the morphology motility